Current Medicinal Chemistry

ISSN: 0929-8673 - Volume 15, 30 Issues, 2008

Editor-in-Chief:

Atta-ur-Rahman, FRS
HEJ Research Institute of Chemistry
University of Karachi, Karachi-75270
Pakistan

Co-Editors:

David Fairlie
Univ. of Queensland, Brisbane
Australia


William J. Hoekstra
Viamet Pharmaceuticals
Durham, NC
USA


Bernard Pirotte
Universite de Liege
Liege
Belgium

Associate Editors:

Wolf-Rainer Abraham (Helmholtz Center for Infection Research, Braunschweig, Germany)
Pier Giovanni Baraldi (Universita' di Ferrara, Ferrara, Italy)
Susanna Fürst (Semmelweis Univ. of Med., Budapest, Hungary)
Francis Johnson (State Univ. of New York, New York, USA)
Alan P. Kozikowski (University of Illinois at Chicago, Chicago, Illinois, USA)
Koichi Shudo (Itsuu Laboratory, Tokyo, Japan)

Editorial Advisory Board:

James David Adams, Jr (University of Southern California, Los Angeles, USA)
Sabbir Ahmad (Kingston University, Surrey, UK)
Hans-Joachim Anders (University of Munich, Munich, Germany)
Vasso Apostolopoulos (M.B.I.M.R.P.H. Ltd., Heidelberg, Australia)
Khusru Asadullah (CRBA Inflammation Schering AG, Berlin, Germany)
Giorgio Ascoli (George Mason University, Fairfax, VA, USA)
Mitchell A. Avery (University of Mississippi, Mississippi, USA)
Michael Aviram (Rambam Medical Center, Haifa, Israel)
J. Baranowska-Kortylewicz (Univ. of Nebraska Medical Center, Nebraska, USA)
Daniela Barlocco (Istituto di Chimica Farmaceutica e Tossicologica, Milano, Italy)
Doris M. Benbrook (University of Oklahoma HSC, Oklahoma, USA)
Wesley G. Bentrude (Univ. of Utah, Salt Lake City, USA)
David B. Berkowitz (University of Nebraska Lincoln, Nebraska, USA)
Mark S. Berridge (Univ. Hospital of Cleveland, Cleveland, USA)
Gildas Bertho (Université René Descartes -Paris V, Paris, France)
Federico Bertuzzi (Mediterranean Institute, Palermo, Italy)
Apurba K. Bhattacharjee (Walter Reed Army Inst. of Res., Silver Spring, MD, USA)
Mark G. Bock (Merck, Westpoint, USA)
Nicholas Bodor (University of Florida, Florida, USA)
Gunther Bonn (University of Innsbruck, Innsbruck, Austria)
Guglielmo Borgia (University of Naples, Naples, Italy)
John B. Bremner (University of Wollongong, Wollongong, Australia)
Catherine Brenner (University of Versailles, Versailles, France)
Roberta Budriesi (University of Bologna, Bologna, Italy)
John K. Buolamwini (Univ. of Mississippi, Mississippi, USA)
Terrence R. Burke Jr (National Inst. of Health, Bethesda, USA)
Joaquín Campos (University of Granada, Granada, Spain)
Anna Capasso (University of Salerno, Salerno, Italy)
Alain Carpy (Universite de Bordeaux I, Talence, France)
Guido Cavaletti (University of Milan "Bicocca", Milan, Italy)
Sebastiano Cavallaro (Italian National Research Council, Catania, Italy)
Jonathan B. Chaires (University of Louisville, Louisville, KY, USA)
Chen Chen (Prince Henry's Institute of Medical Research, Victoria, Australia)
Ji-Wang Chern (National Taiwan University, Taipei, Taiwan)
Peter Chiba (Institute of Medical Chemistry, Vienna, Austria)
Giuseppe Cirino (University of Naples Federico II, Naples, Italy)
Agata G. Copani (University of Catania, Catania, Italy)
Thibaud Coradin (LCMCP, Paris, France)
Gabriele Costantino (University of Perugia, Perugia, Italy)
Maria Paola Costi (Università di Modena e Reggio Emilia, Modena, Italy)
David J. Craik (University of Queensland, St. Lucia, Australia)
Michael A. Crawford (London Metropolitan University, London, UK)
Mark Timothy David Cronin (Liverpool John Moores University, Liverpool, UK)
Silvio Danese (Institute of Clinician Humanitas, Milan, Italy)
Giovanni Davì (University School of Medicine, Chieti, Italy)
Eugene A. Davidson (Georgetown Univ., Washington DC, USA)
Vadim V. Demidov (Boston University, Boston, USA)
Jean-Michel Dogné (University of Namur, Namur, Belgium)
Annette M. Doherty (Pfizer Global Research & Development, Kent, UK)
Steven M. Dubinett (Jonsson Compr. Cancer Ctr, Los Angeles, CA, USA)
Thomas Efferth (German Cancer Research Center, Heidelberg, Germany)
Stefan Eichmuller (University of Heidelberg, Heidelberg, Germany)
Lothar Elling (RWTH Aachen University, Aachen, Germany)
Ling Eng-Ang (National University of Singapore, Singapore)
Ramon Eritja (Institut de Biologia Molecular de Barcelona, Barcelona, Spain)
Vincenzo De Filippis (University of Padua, Padua, Italy)
Paul Fowler (University of Aberdeen, Aberdeen, UK)
Matthias Gaestel (Institut of Biochemistry, Hannover, Germany)
Markus Galanski (University of Vienna, Vienna, Austria)
Roberto Gambari (University of Ferrara, Ferrara, Italy)
Donald R. Gehlert (Lilly Research Laboratories, Indianapolis, USA)
Luca Gentilucci (University of Bologna, Bologna, Italy)
Ana Martinez Gil (Avda. de la Industria 52, Madrid, Spain)
David Goodsell (The Scripps Research Institute, La Jolla, USA)
Marco Guazzi (University of Milan, Milan, Italy)
Alain Gueiffier (Medicinal Chemistry laboratory, Tours, France)
Angel Guerrero (IIQAB-CSIC, Barcelona, Spain)
Andrea Guiotto (University of Padova, Padova, Italy)
Steven E. Hall (Sphinx Pharm., Durham, USA)
John Bondo Hansen (Novo Nordisk A/S, Bagsværd, Denmark)
Isabel Haro (IIQAB, Barcelona, Spain)
Laszlo Gabor Harsing (EGIS Pharmaceuticals Plc, Budapest, Hungary)
Stefan Heckl (University of Tübingen, Tübingen, Germany)
Piet Herdewijn (Rega Institute for Medical Research, Leuven, Belgium)
Dominique Heymann (University of Nantes, Nantes, France)
Werner Hoffmann (Otto-von-Guericke-University, Magdeburg, Germany)
Paul Hofman (Laboratory of Clinical and Experimental Pathology, Nice, France)
T. Högberg (7TM Pharma A/S Fremtidsvej 3, Hoersholm, Denmark)
Ron Hogg (University of Geneva, Geneva, Switzerland)
John F. Honek (University of Waterloo, Ontario, Canada)
K. Hostettmann (Univ. Lausanne, Lausanne, Switzerland)
Robert Hudkins (Cephalon, Inc., West Chester, PA, USA)
Kenji Izuhara (Saga Medical School, Saga, Japan)
Ann L. Jackman (Inst. Cancer Res, Sutton, UK)
G. Jaouen (C.N.R.S, Paris, France)
Wolfgang Ernst Bernhard Jelkmann (University of Lubeck, Lubeck, Germany)
Robert M. Jones (Arena Pharmaceuticals, San Diego, USA)
Mankil Jung (Yonsei Univ, Seoul, Korea)
Huba Kalász (Semmelweis University, Budapest, Hungary)
Hideaki Kaneto (Osaka University, Osaka, Japan)
Dongchon Kang (Kyushu University, Fukuoka, Japan)
Nikos Karamanos (University of Patras, Patras, Greece)
Michael Kassiou (Royal Prince Alfred Hospital, Camperdown, Australia)
Saeed R. Khan (Johns Hopkins Medical Institutions, Baltimore, MD, USA)
Matthew C. Kiernan (University of New South Wales, Randwick, Australia)
Danijel Kikelj (University of Ljubljana, Ljubljana, Slovenia)
Fabian Kiessling (German Cancer Research Center, Germany)
Thomas Klonisch (University of Manitoba, Manitoba, Canada)
Roland Krämer (Universität Heidelberg, Heidelberg, Germany)
Felix Kratz (Tumor Biology Center, Freiburg, Germany)
Vladimir Kren (Institute of Microbiology, Prague, Czech Republic)
Guha Krishnasswamy (James H. Quillen V.A. Medical Center, USA)
Hugo Kubinyi (University of Heidelberg, Heidelberg, Germany)
Donald J. Kyle (Purdue Pharma L.P, Cranbury, NJ, USA)
Patrick Y. Lam (Bristol-Myers Squibb Co, Princeton, USA)
Didier M. Lambert (Univ. Cath. de Louvain, Brussels, Belgium)
Edmond J. LaVoie (Ernest Mario School of Pharmacy, New Jersey, USA)
Frederic R. Leroux (University Louis Pasteur, Strasbourg, France)
Ricahrd A. Lewis (Novartis Pharma, Basel, Switzerland)
Jean-François Liégeois (University of Liège, Liège, Belgium)
Andrzej W. Lipkowski (Polish Academy of Sciences, Warsaw, Poland)
María L López-Rodríguez (Universidad Complutense de Madrid, Madrid, Spain)
Franco Lori (RIGHT, Pavia , Italy)
Mauro Maccarrone (University of Teramo, Teramo, Italy)
Sohail Malik (BioFrontiers, Inc., Redmon, WA, USA)
Marcos Malumbres (Spanish National Cancer Research Center, Madrid, Spain)
Roberto Manfredi (University of Bologna, Bologna, Italy)
Raimund Mannhold (Heinrich-Heine University, Dusseldorf, Germany)
Alberto M. Martelli (University of Bologna, Bologna, Italy)
Ana Martinez (Instituto de Quimica Medica-CSIC, Madrid, Spain)
B.E. Maryanoff (Drug Discov. Johnson & Johnson Pharm., Spring House, USA)
Bernard Masereel (University of Namur, Namur, Belgium)
Elena Matteucci (University of Pisa, Pisa, Italy)
Ian A. McDonald (Pharmaxis Ltd., Frenchs Forest, Australia)
Ross McGeary (The University of Queensland, Brisbane, Australia)
Kapil Mehta (UT M.D. Anderson Cancer Center, Houston, USA)
Shamal Mehta (Ambit Biosciences, San Diego, USA)
Thierry Meinnel (Centre National de la Recherche Scientifique, Cedex, France)
Nahum Mendez-Sanchez (Medica Sur Clinic & Foundation, Mexico City, Mexico)
Hiroyuki Miyachi (University of Tokyo, Tokyo, Japan)
Yoshiyuki Mizushina (Kobe-Gakuin University, Hyogo, Japan)
Alan R. Morgan (PDT Pharmaceuticals, Santa Barbara, USA)
Ryuichi Morishita (Osaka University, Osaka, Japan)
Stefano Moro (University of Padova, Padova, Italy)
Andrea Mozzarelli (University of Parma, Parma, Italy)
Diego Munoz-Torrero (University of Barcelona, Barcelona, Spain)
Sunil Nagpal (Wyeth Research, Collegeville, PA, USA)
John J. Nestor, Jr (TheraPei Pharmaceuticals, Inc, San Diego, USA)
Amy Hauck Newman (National Institutes of Health, Baltimore, USA)
Ion Niculescu-Duvaz (CR-UK Labs, Surrey, UK)
Toshio Nishikimi (Dokkyo Medical University, Tochigi, Japan)
Douglas Noonan (University of the Studies of the insubria, Varese, Italy)
Joe O'Connell (NUIC, Cork, Ireland)
D.W. Oliver (Potchefstroom Univ, Potchefstroom, South Africa)
Yoshihiro Oka (Osaka University, Osaka, Japan)
Kenji Okajima (Nagoya City University, Nagoya, Japan)
Mark Overhand (Leiden University, Leiden, The Netherlands)
Pal Pacher (NIAAA/NIH, Bethesda, MD, USA)
Krysztof W. Pankiewicz (Univ. of Minnesota, Minneapolis, MN, USA)
Athanasios G. Papavassiliou (University of Athens, Athens, Greece)
José Manuel Pérez (Autonomous University of Madrid, Madrid, Spain)
Ruy Perez-Montfort (Universidad Nacional Autonoma de Mexico, Mexico)
Ricardo Pérez-Tomás (University of Barcelona, Barcelona, Spain)
George Perry (University of Texas at San Antonio, Texas, TX, USA)
Bernard M. Pettit (Univ. Houston, Houston, USA)
John M. Pezzuto (Purdue University, West Lafayette, USA)
Victor W. Pike (National Institutes of Health, Bethesda, MD, USA)
M.R.A. Pillai (International Atomic Energy Agency, Vienna, Austria)
Ulf Pindur (University of Mainz, Mainz, Germany)
Piero Portincasa (University Medical School of Bari, Bari, Italy)
Waldemar Priebe (The University of Texas, Houston, TX, USA)
Laszlo Prokai (University of North Texas Health Science Center, Texas, USA)
Milica S. Prostran (University of Belgrade, Belgrade, Serbia)
Markus Reindl (Innsbruck Medical University, Innsbruck, Austria)
Giampaolo Ricci (University of Bologna, Bologna, Italy)
K.L. Rinehart (Univ. Illinois, Urbana-Champaign, USA)
Tadeusz Robak (Medical University of Lodz, Cio kowskiego, Poland)
Giovanna Romeo (Sapienza University of Rome, Rome, Italy)
Basil Roufogalis (University of Sydney, Sydney, Australia)
Patrizia Anna Russo (National institute for the Search on the Cancer, Genoa, Italy)
Sergio Rutella (Catholic University Medical School, Rome, Italy)
Agapios Sachinidis (Institute of Neurophysiology, Cologne, Germany)
Michel Salzet (University of the Sciences and Technology of Lille, Lille, France)
Isidro Sánchez-García (CSIC, Salamanca, Spain)
Moshe Schaffer (Ludwig- Maximillians University, Munich, Germany)
Silvia Schenone (University of Genoa, Genoa, Italy)
Jeffrey D. Schmitt (Mol. Design & IT Group, North Carolina, USA)
M. Lienhard Schmitz (University of Giessen, Giessen, Germany)
Stewart W. Schneller (Auburn University, USA)
Kenneth R. Scott (Howard Univ., Washington, USA)
Alessandro Serretti (University of Bologna, Bologna, Italy)
Patrick M. Sexton (The University of Melbourne, Victoria, Australia)
Barry G. Shearer (GlaxoSmithKline, Research Triangle Park, NC, USA)
Hisashi Shinkai (Central Pharmaceutical Research Institute, Osaka, Japan)
Werner Sieghart (Medical University Vienna, Vienna, Austria)
Robert D. Sindelar (University of British Columbia, Vancouver, Canada)
Drago R. Sliskovic (Pfizer Inc, Ann Arbor, USA)
Yuntao Song (Pfizer Inc, Ann Arbor, USA)
John R.J. Sorenson (Univ. Arkansas, Arkansas, USA)
David S. Soriano (University of Pittsburgh, Bradford, USA)
Giampiero Spalluto (University of Trieste, Trieste, Italy)
Caroline J. Springer (Inst. of Cancer Research, Surrey, UK)
Steven Stacker (Ludwig Institute for Cancer Research, Victoria, Australia)
Holger Stark (Johann Wolfgang Goethe-Universitaet, Frankfurt, Germany)
Juan Carlos Stockert (University of Madrid, Madrid, Spain)
Claudiu T. Supuran (University of Florence, Firenze, Italy)
Nikos Tagmatarchis (Inst. of Theor. and Phys. Chem, Athens, Greece)
James E. Talmadge (University of Nebraska Medical Center, Omaha, NE, USA)
Igor V. Tetko (Institute of Bioinformatics, Neuherberg,Germany)
Bharat K. Trivedi (Parke-Davis, Ann Arbor, USA)
Jakob Troppmair (Innsbruck Medical University, Innsbruck, Austria)
John Varghese (Athena Neurosciences, San Francisco, USA)
Gerrit Herman Veeneman (Organon, Oss, The Netherlands)
Sauro Vittori (University of Camerino, Camerino, Italy)
Wolfgang Voelter (University of Tübingen, Tübingen, Germany)
Nicola Volpi (University of Modena & Reggio Emilia, Modena, Italy)
De-Yun Wang (The National University of Singapore, Singapore)
Steven M. Weinreb (Penn. State Univ, University Park, USA)
John S. Williamson (University of Mississippi, Mississippi, USA)
Gordon Willick (National Research Council, Ottawa, Canada)
Jörg Wilting (University of Göttingen, Göttingen, Germany)
Zbigniew J. Witczak (Wilkes University, Wilkes-Barre, USA)
Yung H. Wong (Hong Kong University of Science and Technology, Hong Kong)
Ruiwen Zhang (University of Alabama, Birmingham, USA)