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Recent Patents
on Cardiovascular Drug Discovery
ISSN: 1574-8901 - Volume 5, 3 Issues, 2010
Instructions for Authors
Regular manuscripts may be submitted directly
to the Editorial Office by e-mail to patents@bentham.org
or prc@bentham.org
ONLINE MANUSCRIPT SUBMISSION: An online submission
and tracking service via internet facilitates a speedy and
cost-effective submission of manuscripts. The full manuscript
should be submitted online via Bentham's Content Management
System (CMS) at www.bentham-editorial.org
(View
Instructions) online.
Manuscripts must be submitted by one of the authors of the
manuscript, and should not be submitted by anyone on their
behalf. The principal/corresponding author will be required
to submit a Cover Letter along with the manuscript, on behalf
of all the co-authors (if any) to confirm that the manuscript
(or any part of it) has not been published previously or is
not under consideration for publication elsewhere. Furthermore,
any illustration, structure or table that has been published
elsewhere must be reported, and copyright permission for reproduction
must be obtained. The figures from patent documents are freely
available on the databases and may not require any permission
unless stated otherwise.
For all online submissions, please provide soft copies of
all the materials (main text in MS Word or Tex/LaTeX), figures
/ illustrations in TIFF, PDF or JPEG, and chemical structures
drawn in ChemDraw (CDX) / ISISDraw (TGF) as separate files,
while a PDF version of the entire manuscript must also be
included, embedded with all the figures/ illustrations/tables/chemical
structures etc.
It is imperative that before submission, the author(s) should
carefully proofread the files for special characters, mathematical
symbols, Greek letters, equations, tables, references and
images to ensure that they appear in proper format.
References, figures, tables, chemical structures, etc. should
be referred to in the text at the appropriate places where
they have been first discussed. Figure legends/ captions should
also be provided.
A successful electronic submission of the manuscript will
be confirmed by a system-generated email acknowledgement to
the principal/corresponding author immediately. Any queries
therein should be addressed at patents@bentham.org
MANUSCRIPTS PUBLISHED: The journal accepts
mini- and full-length review articles written in English.
Single Topic/ Thematic Issues by invited Guest Editors are
also considered for publication.
Thematic Issues: Potential Guest
Editors (GE) have to submit a brief description of the proposed
topic outlining the aims & scope of the issue, the list
of titles with author names and affiliations, and keywords
on recent patents to be discussed in the proposed title. The
GE and the authors will also provide specific keywords other
than already in the titles for the compilation of the patent
selection.
The Thematic Issue will need to have about 100-120 printed
pages from contributions by 6 to 8 authors. Alternatively,
a Mini-Thematic Issue can also be considered whereby half
the required number of pages and contributors (i.e. 3 to 4
authors) would be required.
The GE is responsible to review the complete issue and forward
the finalized manuscripts along with an ‘Editorial’
to the journal's Editor-in-Chief for approval, within the
given timeframe. Proposal may be submitted to patents@bentham.org
Patent Selections: A separate section
of important and recent patents on cardiovascular drug discovery
is also included in the journal. The patents annotated in
this section are relevant to the articles published in this
journal issue, categorized by therapeutic areas/targets and
therapeutic agents related to cardiovascular drug discovery.
MANUSCRIPT LENGTH: Page lengths can vary
for mini-reviews of up to 9 journal pages and for longer reviews
up to 30 journal pages. A printed journal page is ca. 900
words (excluding diagrams and figures). There is no restriction
on the number of patents, figures or tables in the manuscript.
MANUSCRIPT PREPARATION: The manuscript should
be written in English in a clear, direct and active style.
All pages must be numbered sequentially, facilitating in the
reviewing and editing of the manuscript. For further convenience,
the customer support team available at Bentham Publishing
Services (www.benthampublishingservices.com)
can provide assistance to authors for the preparation of manuscripts.
MANUSCRIPT SECTIONS FOR PAPERS:
Manuscripts for review articles submitted to the journal may
be divided into the following sections:
1. Cover Letter: It is mandatory to submit
a signed covering letter along with the manuscript, by the
author to whom correspondence is to be addressed, delineating
the scope of the submitted article declaring the potential
competing interests, acknowledging contributions from authors
and funding agencies, and certifying that the paper is prepared
according to the 'Instructions for Authors'.
All inconsistencies in the text and in the reference section
and any typographical errors must be carefully checked and
corrected before the submission of the manuscript. The article
should not contain any material or information that may be
unlawful, defamatory, fabricated, plagiarized, or which would,
if published, in any way whatsoever, violate the terms and
conditions as laid down in the copyright agreement. The authors
should acknowledge that the publishers have the legal right
to take appropriate action against the authors for any such
violation of the terms and conditions as laid down in the
copyright agreement. To download the cover letter, please
visit: www.bentham.org/prc/COVERING-LETTER.doc
2. Title: The title of the article should
be precise and brief and must not be more than 120 characters.
Authors should avoid the use of non-standard abbreviations.
The title must be written in title case except for articles,
conjunctions and prepositions. Title, running title, byline,
correspondent footnote and keywords should be written as presented
in original manuscript.
3. Short Running Title: Authors must provide
a short ‘running title’ of their manuscript.
4. Authors’ Names and Affiliations:
The names of the authors should be provided according to previous
citations or as the authors would want them to be published
along with the institutional affiliations and current address,
telephone, cell & fax numbers and the email address must
be provided, with an asterisk in front of the name of the
principal author. The corresponding author should also be
designated and the full address, telephone, cell & fax
numbers and the email address must be stated to receive correspondence
and galley proofs.
5. Abstract: The abstract summarizing the
essential features of the review article should not exceed
200 words and must include information regarding patents.
6. Keywords: Authors must provide 6 to 8
keywords in alphabetical order.
7. Text Organization: The manuscript should
be divided as: Title page, abstract and the main text. The
text may be subdivided further according to the areas to be
discussed. The acknowledgements (if any) and the references
section must then follow. The Review Article should mention
any previous important, recent and old reviews in the field
and contain a comprehensive discussion starting with the general
background of the field. It should then go on to discuss the
salient features of recent developments along with relevant
patents. The authors should avoid presenting material which
has already been published in a previous review. The authors
are advised to present and discuss their observations in brief.
The manuscript style must be uniform throughout the text and
10pt Times New Roman fonts should be used. The full term for
an abbreviation should precede its first appearance in the
text unless it is a standard unit of measurement. Italics
should be used for Binomial names of organisms (Genus and
Species), for emphasis and for unfamiliar words or phrases.
Non-assimilated words from Latin or other languages should
also be italicized e.g. per se, et al., in vitro, in vivo,
in situ, etc.
Patent Review Coverage: Authors
should review the most recent and important patents based
on the topic covered. Coverage of novel bioactive compounds,
analogs & targets, techniques and drug design in all areas
of cardiovascular drug discovery should be emphasized, including
the significance of reported patents.
Current & Future Developments:
The review article should conclude with a short section called
“Current & Future Developments”. The author(s)
will give their opinion on the current and future important
developments on the topic discussed in their article.
Symbols and Units: Greek symbols
and special characters often undergo formatting changes and
get corrupted or lost during preparation of a manuscript for
publication. To ensure that all special characters used are
embedded in the text, these special characters should be inserted
as a symbol but should not be a result of any format styling
(Symbol font face) otherwise they will be lost during the
conversion to PDF/XML.
Authors are encouraged to consult reporting guidelines. These
guidelines provide a set of recommendations comprising a list
of items relevant to their specific research design.
Only ISO symbols, written in italic, should be used for the
various parameters. All kinds of measurements should be reported
only in International System of Units (SI). SI units should
always be written in Roman and separated from the numerical
value by a space (whatever the language).
The μ
in µg or µm should be in Roman. The symbol for
litre is L and that for minute is min. For temperature, please
use only one of °C, °F or K in the entire manuscript.
As the Angström (1#Å = 10-10
m) is not an SI unit, it should be replaced by the nanometre
(1nm = 10-9 m) or by the
picometer (1pm = 10-12 m):
1# Å = 0.1nm = 100 pm. Multiple units should be written
with negative superscripts (for example, 25mgμL-1µs-1).
The list of notations should appear just before the first
paragraph of full text.
A list of symbols and units should be provided if used extensively
throughout the text.
8. List of Abbreviations: If abbreviations
are used in the text either they should be defined in the
text where first used, or a list of abbreviations can be provided.
9. Acknowledgements: Financial contributions
to the work being reported should be clearly acknowledged.
Please acknowledge anyone (individual/company/institution)
who has contributed to the study by making substantial contributions
to conception, design, acquisition of data, or analysis and
interpretation of data, or who was involved in drafting the
manuscript or revising it critically for important intellectual
content. Please list the source(s) of funding for the study,
for each author, and for the manuscript preparation in the
acknowledgement section.
This journal complies with the International Committee of
Medical Journal Editors' Uniform Requirements for Manuscripts
Submitted to Biomedical Journals www.icmje.org
and the FDA's Good Reprint Practices for the Distribution
of Medical Journal Articles and Medical or Scientific Reference
Publications on Unapproved New Uses of Approved Drugs and
Approved or Cleared Medical Devices
www.fda.gov/oc/op/goodreprint.html
10. Conflict of Interest: Any potential conflict
of interest should be clearly acknowledged. No patents should
be cited by authors that are in various stages of legal litigation.
11. References: References should be numbered
sequentially [in square brackets] in the text and listed in
the same numerical order in the reference section. All references
must be complete and accurate. Online citations should include
the date of access. Journal titles should conform to the present
Index Medicus abbreviations. It is necessary to list all authors
if the total number of authors is 6 or less, and for more
than 6 authors list the first 6 authors and then use et al.
The reference numbers must be finalized and the bibliography
must be fully formatted before submission.
References should be listed in the following Vancouver Style:
[1] Journal: Boehm M, Nabel EG.
Angiotensin-converting enzyme 2 - A new cardiac regulator.
N Engl J Med 2002; 347: 1795-7.
[2] Book: Crabtree RH. The Organometallic
Chemistry of the Transition Metals. 3rd ed. Wiley & Sons:
New York 2001.
[3] Book Chapter: Yeh DC, Rocco
T. In: David EG, Armen HT, Ehrin JA, April WA, Eds. Integrative
Cardiovascular Pharmacology. Philadelphia: Lippincott Williams
& Wilkins 2005: 375-83.
[4] Conference Proceedings: Jakeman
DL, Withers SGE. Carbohydrate Bioengineering: Interdisciplinary
Approaches. Proceedings of the 4th
Carbohydrate Bioengineering Meeting. Stockholm, Sweden,
June 10-13, 2001.
[5] Meeting Abstract: Hoffman, BJ.
Metabolism: Amino acid transporters as targets for therapeutic
intervention. American Chemical Society - 228th
National Meeting. Philadelphia, USA (2004).
[6] Website: National Library of
Medicine. Specialized Information Services: Toxicology and
Environmental Health. Available at:
http://sis.nlm.nih.gov/Tox/ToxMain.html. (Accessed on: May
23, 2009).
[7] Thesis: Mackel H. Capturing
the Spectra of Silicon Solar Cells. PhD Thesis, The Australian
National University, Canberra, Australia, December 2004.
[8] Patent: As
a service, the Publishers can provide each author a certain
number of relevant patents to assist them in writing their
article. All patent application references will be provided
by the author and will be published as it is.
Patent Reference Style: All inventors’
names of the cited patents must be stated with the title,
publication number and the year of publication e.g. Chesnut,
J.D., Carrino, J., Leong, L., Madden, K., Gleeson, M.A.G.,
Fan, J., Brasch, M.A., Cheo, D., Hartley, J.L., Byrd, D.R.N.,
Temple, G.F.
Methods and compositions for synthesis of nucleic acid molecules
using multiple recognition sites. US7198924 (2007).
Citation of the patents will be according to the international
convention as follows:
• WO Patents: 1978-2003
Yue, S., Johnson, I., Haugland, R. Dimers of unsymmetrical
cyanine dyes. WO9306482 (1993).
Li, Q., Guo, Z.Y., Kane, T., Liu, Z. System and method for
temperature gradient capillary electrophoresis. WO03033743
(2003).
• WO Patents: 2004 onwards Abad, A.,
Dong, H., Lo, S.B., McCutchen, B.F., Shi, X. Method for identifying
novel genes. WO2008011565 (2008).
• US Patent Applications: 2001 onwards
Adang, A.E.P., Van Boeckel, C.A.A., Peters, J.A.M., Grootenhuis,
P.D.J. Thrombin inhibitors. US20010007764 (2001).
Stefanadis, C., Kipshidze, N. Method and devices for treatment
of vulnerable (unstable) and/or stable atherosclerotic plaque
by disrupting pathologic vasa vasorum of the atherosclerotic
plaque. US20090030494 (2009).
• Issued/ Granted US Patents:
Hultmark, D., Steiner, H., Rasmuson, T., Boman, H.G. Bacteriolytic
proteins. US4355104 (1982).
Garbe, C., Schittek, B. Antimicrobially active peptide. US7348409
(2008).
• EP Patents:
Sutherland, J.W., Patterson, D.R. Homogeneous method for assay
of double-stranded nucleic acids using fluorescent dyes and
kit useful therein. EP684316 (1995).
Une, K., Saito, J., Hayashi, T. Method for assaying Reg IV
mRNA. EP1780289 (2007).
Some important points to remember:
• Superscripts in the in-text citations and reference
section should be avoided.
• Abstracts, unpublished data and personal communications
(which can only be included if prior permission has been obtained)
should not be given in the reference section but they may
be mentioned in the text and details provided as footnotes.
• The authors are encouraged to use a recent version
of EndNote (version 5 and above) or Reference Manager (version
10) when formatting their reference list, as this allows references
to be automatically extracted.
12. Tables:
• Data tables should be submitted in Microsoft Word
table format.
• Each table should include a title/caption being explanatory
in itself with respect to the details discussed in the table.
Detailed legends may then follow.
• Table number in bold font i.e. Table 1,
should follow a title. The title should be in small case with
the first letter in caps. A full stop should be placed at
the end of the title.
• Tables should be embedded in the text exactly according
to their appropriate placement in the submitted manuscript.
• Columns and rows of data should be made visibly distinct
by ensuring that the borders of each cell are displayed as
black lines.
• Tables should be numbered in Arabic numerals sequentially
in order of their citation in the body of the text.
• If a reference is cited in both the table and text,
please insert a lettered footnote in the table to refer to
the numbered reference in the text.
• Tabular data provided as additional files can be submitted
as an Excel spreadsheet.
13. Figures / Illustrations: The quality of
the illustrations printed in the journal largely depends on
the quality of the figures/ illustration provided by the author.
The acceptance of a manuscript for publication is subject
to the figures being up to the highest standards in terms
of clarity and resolution. In case, the figures supplied are
not up to the standards required, the authors will be given
the option to either return the manuscripts within one week
with appropriate drawings/figures or they may opt to have
these professionally prepared through the paid professional
service available from Bentham Publishing Services.
The authors should provide the illustrations as separate files,
as well as embedded in the text file, numbered consecutively
in the order of their appearance. Each figure should include
a single illustration. Each figure should be closely cropped
to minimize the amount of white space surrounding the illustration.
If a figure consists of separate parts, it is important that
a single composite illustration file be submitted, containing
all parts of the figure.
Photographs should be provided with a scale bar if appropriate,
as well as high-resolution component files.
Scaling / Resolution:
For Line Art image type, which is generally an image based
on lines and text and does not contain tonal or shaded areas,
the preferred file format is TIFF or EPS, with color mode
being Monochrome 1-bit or RGB, in a resolution of 900-1200
dpi.
For Halftone image type, which is generally a continuous tone
photograph and contains no text, the preferred file format
is TIFF, with color mode being or RGB or Grayscale, in a resolution
of 300 dpi.
For Combination image type, which is generally an image containing
halftone in addition to text or line art elements, the preferred
file format is TIFF, with colour mode being or RGB or Grayscale,
in a resolution of 500-900 dpi.
Formats:
For illustrations, the following file formats are acceptable:
• Illustrator
• EPS (preferred format for diagrams)
• PDF (also especially suitable for diagrams)
• PNG (preferred format for photos or images)
• Microsoft Word (version 5 and above; figures must
be a single page)
• PowerPoint (figures must be a single page)
• TIFF
• JPEG (conversion should be done using the original
file)
• BMP
• CDX (ChemDraw)
• TGF (ISISDraw)
Bentham Science does not process figures submitted
in GIF format.
If the large size of TIFF or EPS figures acts as an obstacle
to online submission, authors may find that conversion to
JPEG format before submission results in significantly reduced
file size and upload time, while retaining acceptable quality.
JPEG is a 'lossy' format, however. In order to maintain acceptable
image quality, it is recommended that JPEG files are saved
at high or maximum quality.
Files should not be compressed with tools such as Zipit or
Stuffit prior to submission as these tools will in any case
produce negligible file-size savings for JPEGs and TIFFs,
which are already compressed.
Please do not:
1. Supply embedded graphics in your word processor (spreadsheet,
presentation) document;
2. Supply files that are optimized for screen use (like GIF,
BMP, PICT, WPG); the resolution is too low;
3. Supply files that are too low in resolution;
4. Submit graphics that are disproportionately large for the
content.
Image Conversion Tools:
There are many software packages, many of them freeware or
shareware, capable of converting to and from different graphics
formats, including PNG.
Good general tools for image conversion include GraphicConverter
on the Macintosh, PaintShop Pro, for Windows, and ImageMagick,
which is available on Macintosh, Windows and UNIX platforms.
Note that bitmap images (e.g. screenshots) should not be converted
to EPS, since this will result in a much larger file size
than the equivalent JPEG, TIFF, PNG or BMP, with no increase
in quality. EPS should only be used for images produced by
vector-drawing applications such as Adobe Illustrator or CorelDraw.
Most vector-drawing applications can be saved in, or exported
as, EPS format. In case the images have been originally prepared
in an Office application, such as Word or PowerPoint, then
the original Office files should be directly uploaded to the
site, instead of being converted to JPEG or another format
that may be of low quality.
Color Figures / Illustrations
• The cost for the first published page of color figures
is US$ 893; the second additional page will
be for US$ 652 and each subsequent page for
US$ 441.
• Color figures should be supplied in CMYK not RGB colors.
14. Chemical Structures:
Chemical structures MUST be prepared in ChemDraw (CDX) and
provided as separate file.
Structure Drawing Preferences:
[As according to the ACS style sheet]
Drawing Settings:
Chain angle 120°
Bond spacing 18% of width
Fixed length 14.4
pt (0.500cm, 0.2in)
Bold width
2.0 pt (0.071cm, 0.0278in)
Line width 0.6
pt (0.021cm, 0.0084in)
Margin width 1.6 pt
(0.096cm)
Harsh spacing 2.5 pt (0.088cm, 0.0347in)
Text settings:
Font
Times New Roman
Size
8 pt
Under the Preference Choose:
Units
points
Tolerances 3
pixels
Under Page Setup Use:
Paper
US letter
Scale
100%
15. Supportive/ Supplementary Material: We
do encourage to append supportive material, for example a
PowerPoint file containing a talk about the study, a PowerPoint
file containing additional screenshots, a Word, RTF, or PDF
document showing the original instrument(s) used, a video,
or the original data (SAS/SPSS files, Excel files, Access
Db files etc.) provided it is inevitable or endorsed by the
journal's Editor.
Published/Reproduced material should not be included unless
you have obtained written permission from the copyright holder,
which must be forwarded to the Editorial Office in case of
acceptance of your article for publication.
Supportive/Supplementary material intended for publication
must be numbered and referred to in the manuscript but
should not be a part of the submitted paper. In-text
citations as well as a section with the heading "Supportive/Supplementary
Material" before the "References" section should
be provided. Here, list all Supportive/Supplementary Material
and include a brief caption line for each file describing
its contents.
Any additional files will be linked into the final published
article in the form supplied by the author, but will not be
displayed within the paper. They will be made available in
exactly the same form as originally provided only
on our website. Please also make sure that each additional
file is a single table, figure or movie (please do not upload
linked worksheets or PDF files larger than one sheet). Supportive/
Supplementary material must be provided in a single zipped
file not larger than 4 MB.
Authors must clearly indicate if these files are not for publication
but meant for the reviewers'/editors' perusal only.
PERMISSION FOR REPRODUCTION: Published/reproduced
material should not be included unless you have obtained written
permission from the copyright holder, which should be forwarded
to the Editorial Office in case of acceptance of your article
for publication.
For obtaining permission of reproducing any material published
in an article by Bentham Science Publishers, please
fill in the request FORM
downloadable from the journal’s Web site and send to
patents@bentham.org
for consideration.
REVIEWING AND PROMPTNESS OF PUBLICATION:
All manuscripts submitted for publication will be immediately
subjected to peer-review, usually in consultation with members
of the Editorial Advisory Board. All peer-review will be done
via the internet to facilitate rapid review of submitted manuscripts.
Authors are encouraged, however, to suggest names of possible
referees along with their full names, postal and e-mail addresses,
telephone and fax numbers. Every effort will be made to assess
manuscripts quickly and the decision conveyed to the authors
in due course.
PAGE CHARGES: No page charges will be levied
to the authors.
LANGUAGE EDITING: Manuscripts submitted containing
many English typographical errors will not be published. Authors
from non-English language countries are advised to use the
services of our professional language editing department prior
to submitting their manuscript to the journal. Please contact
Bentham Publishing Services (www.benthampublishingservices.com)
for a language editing quote via e-mail at: info@benthampublishingservices.com
stating the total number of words of the article to be edited.
PROOFS: Authors will receive page proofs
of their accepted paper before publications. To avoid delays
in publication, proofs should be checked immediately for typographical
errors and returned within 48 hours. Major changes are not
acceptable at the proof stage. If unable to send corrections
within 48 hours due to some reason, the author(s) must at
least send an acknowledgement on receiving the galley proofs
or the article will be published exactly as received and the
publishers will not be responsible for any error occurring
in the published manuscript in this regard.
The corresponding author will be solely responsible for ensuring
that the revised version of the manuscript incorporating all
the submitted corrections receives the approval of all the
co-authors of the manuscript.
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to publication of the article. First named authors may also
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at 50% off the normal subscription rate by contacting the
subscription department at e-mail: subscriptions@bentham.org
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For more information please contact us at e-mail: openaccess@bentham.org
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